Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan

• Main Authors: Ahmed Elbadri, Atia, Ku Zaifah, Norsidah, Abdullah, Nor Zamzila, Mokhtar, Rafidah Hanim, Draman, Samsul, Md Aris, Mohd Aznan, Abdul Rahman, Rashidah, A.Talib, Norlelawati
• Format: Article
• Language: English
• Published: Malaysian Medical Association 2012
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/24402/1/Atia_et.al_paper_2012.pdf; http://irep.iium.edu.my/24402/; http://www.e-mjm.org/2012/v67n1/Polymorphism.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Polymorphisms within the beta2-adrenergic receptor (ADRB2) gene have been repeatedly linked to hypertension. Among the ADRB2 polymorphisms detected, Arg16Gly and Gln27Glu codons are considered the two most important variations. The amino acid substitution at these codons may lead to abnormal regulat...