Molecular genetic analysis of phosphatase and tensin homolog and p16 tumor suppressor genes in patients with malignant glioma

• Main Authors: Abdullah, Jafri Malin, Zainuddin, Norafiza, Sulong, Sarina, Isa, Mohd. Nizam, Jaafar, Hasnan
• Format: Article
• Language: English
• Published: Journal of Neurosurgery Publishing Group 2003
• Subjects: RC254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/30769/1/Ja_Neurosurg_Focus.pdf; http://irep.iium.edu.my/30769/; http://thejns.org/page/about
• Institution: Universiti Islam Antarabangsa Malaysia

Object. Several genes have been shown to carry mutations in human malignant gliomas, including the phosphatase and tensin homolog (PTEN) deleted on chromosome 10 and p16 tumor suppressor genes. Alterations of this gene located on chromosome 10 q23 and 9p21, respectively, may contribute to gliomage...