Syzygium campanulatum korth methanolic extract inhibits angiogenesis and tumor growth in nude mice

• Main Authors: Abdalrahim , FA Aisha, Zhari I, Ismail, Khalid , M Abu-Saleh, Siddiqui, Mohammad Jamshed Ahmad, Ghafar, Gheniya, Shah, Amin Malik
• Format: Article
• Language: English
• Published: BioMed Central 2013
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/30791/1/BMC-12July_2013-Syzygium_campanulatum.pdf; http://irep.iium.edu.my/30791/; http://www.biomedcentral.com/1472-6882/13/168
• Institution: Universiti Islam Antarabangsa Malaysia

Betulinic acid was isolated from methanolic extract by crystallization and chromatography techniques. S.C. methanolic extract was analyzed by UV-Vis spectrophotometry, FTIR, LCMS, and HPLC. Antiangiogenic effect was studied on rat aortic rings, matrigel tube formation, cell proliferation and migra...