Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease

Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia. We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD. Methods: This is a cross-sectional study involving...

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Main Authors: Hashim, Hasnur Zaman, Mohamed Ibrahim, Norlinah, Wan Yahya, Nafisah, Tan, Huijan, Raymond, Azman Ali, Tamil, Azmi Mohd
Format: Article
Language:English
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English
Published: Informa Healthcare 2014
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Online Access:http://irep.iium.edu.my/32386/1/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced.pdf
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http://dx.doi.org/10.3109/00207454.2013.833511
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spelling my.iium.irep.323862017-09-27T04:39:43Z http://irep.iium.edu.my/32386/ Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease Hashim, Hasnur Zaman Mohamed Ibrahim, Norlinah Wan Yahya, Nafisah Tan, Huijan Raymond, Azman Ali Tamil, Azmi Mohd RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia. We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD. Methods: This is a cross-sectional study involving 95 patients with PD on uninterrupted levodopa therapy for at least 6 months. The instrument used was the UPDRS questionnaires. The predictors of dyskinesia were determined using multivariate logistic regression analysis. Results: The mean age was 65.6 ± 8.5 years. The mean onset age was 58.5 ± 9.8 years. The median disease duration was 6 (7) years. Dyskinesia was present in 44% (n = 42) with median levodopa therapy of 3 years. There were 64.3% Chinese, 31% Malays, and 3.7% Indians and other ethnic groups. Eighty-one percent of patients with dyskinesia had clinical fluctuations. Patients with dyskinesia had lower onset age ( p < 0.001), longer duration of levodopa therapy ( p < 0.001), longer disease duration ( p < 0.001), higher total daily levodopa dose ( p < 0.001), and higher total UPDRS scores ( p = 0.005) than patients without dyskinesia. The three significant predictors of dyskinesia were duration of levodopa therapy, onset age, and total daily levodopa dose. Conclusions: The prevalence of levodopa-induced dyskinesia in our patients was 44%. The most significant predictors were duration of levodopa therapy, total daily levodopa dose, and onset age. Informa Healthcare 2014-03 Article REM application/pdf en http://irep.iium.edu.my/32386/1/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced.pdf application/pdf en http://irep.iium.edu.my/32386/2/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/32386/3/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_WOS.pdf Hashim, Hasnur Zaman and Mohamed Ibrahim, Norlinah and Wan Yahya, Nafisah and Tan, Huijan and Raymond, Azman Ali and Tamil, Azmi Mohd (2014) Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease. International Journal of Neuroscience, 124 (3). pp. 187-191. ISSN 0020-7454 http://dx.doi.org/10.3109/00207454.2013.833511 10.3109/00207454.2013.833511
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Hashim, Hasnur Zaman
Mohamed Ibrahim, Norlinah
Wan Yahya, Nafisah
Tan, Huijan
Raymond, Azman Ali
Tamil, Azmi Mohd
Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
description Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia. We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD. Methods: This is a cross-sectional study involving 95 patients with PD on uninterrupted levodopa therapy for at least 6 months. The instrument used was the UPDRS questionnaires. The predictors of dyskinesia were determined using multivariate logistic regression analysis. Results: The mean age was 65.6 ± 8.5 years. The mean onset age was 58.5 ± 9.8 years. The median disease duration was 6 (7) years. Dyskinesia was present in 44% (n = 42) with median levodopa therapy of 3 years. There were 64.3% Chinese, 31% Malays, and 3.7% Indians and other ethnic groups. Eighty-one percent of patients with dyskinesia had clinical fluctuations. Patients with dyskinesia had lower onset age ( p < 0.001), longer duration of levodopa therapy ( p < 0.001), longer disease duration ( p < 0.001), higher total daily levodopa dose ( p < 0.001), and higher total UPDRS scores ( p = 0.005) than patients without dyskinesia. The three significant predictors of dyskinesia were duration of levodopa therapy, onset age, and total daily levodopa dose. Conclusions: The prevalence of levodopa-induced dyskinesia in our patients was 44%. The most significant predictors were duration of levodopa therapy, total daily levodopa dose, and onset age.
format Article
author Hashim, Hasnur Zaman
Mohamed Ibrahim, Norlinah
Wan Yahya, Nafisah
Tan, Huijan
Raymond, Azman Ali
Tamil, Azmi Mohd
author_facet Hashim, Hasnur Zaman
Mohamed Ibrahim, Norlinah
Wan Yahya, Nafisah
Tan, Huijan
Raymond, Azman Ali
Tamil, Azmi Mohd
author_sort Hashim, Hasnur Zaman
title Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_short Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_full Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_fullStr Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_full_unstemmed Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_sort risk factors and predictors of levodopa-induced dyskinesia among multiethnic malaysians with parkinson's disease
publisher Informa Healthcare
publishDate 2014
url http://irep.iium.edu.my/32386/1/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced.pdf
http://irep.iium.edu.my/32386/2/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_SCOPUS.pdf
http://irep.iium.edu.my/32386/3/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_WOS.pdf
http://irep.iium.edu.my/32386/
http://dx.doi.org/10.3109/00207454.2013.833511
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