Metabolomics for bioactivity assessment of natural products
Natural products historically have been a rich source of lead molecules in drug discovery, based on their capability to create unique and diverse chemical structures. However, it is also true that the vast number of metabolites typically present in natural products and their huge dynamic range res...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
John Wiley and Son, Ltd
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/33306/1/Yuliana-N.D._Metabolomics-for-bioactivity-assessment-of-natural-products_2011.pdf http://irep.iium.edu.my/33306/ http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291099-1573 |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English |
| Summary: | Natural products historically have been a rich source of lead molecules in drug discovery, based on their
capability to create unique and diverse chemical structures. However, it is also true that the vast number of
metabolites typically present in natural products and their huge dynamic range results in the loss of many
possibly bioactive natural compounds, becoming an inextricable obstacle for drug development. Recently, new
strategies which favour a holistic approach as opposed to the traditional reductionist methods used previously,
have been introduced with the purpose of overcoming the bottlenecks in natural product research. This
approach is based on the application of new technologies, including metabolomics, for example. Metabolomics
allows a systematic study of a complex mixture such as a phytochemical preparation, which can be linked to
observations obtained through biological testing systems without the need for isolating active principles. This
may put drug discovery from natural products back in the limelight again. In this review paper, the description
of some examples of successful metabolomics applications in several important fields related to drug discovery
from natural sources aims at raising the potential of metabolomics in reducing the gap between natural products
(NP) and modern drug discovery demand. |
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