Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi. Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fracti...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Coastal Life Medicine Media co., Limited
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/33985/1/JCLM_mangostin_direct_and_indirect.pdf http://irep.iium.edu.my/33985/ |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English |
| Summary: | Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi.
Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional inhibitory concentration (FIC).
Results: The activity of all four bacteria towards ampicillin, penicillin G, streptomycin and tetracycline showed no interaction with the combination with α-mangostin where the FIC indexes were between the range of 0.5<FICindex>4. Activity of doxycycline on Pseudomonas aeruginosa fell into other set of range, FICindex≥4 which is an antagonism.
Conclusions: The FIC index is far away in the range. The coupled antibiotic and α-mangostin is considered synergy in action if it lies in FICindex≤0.5 and it was found that the isolated compound, α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics. |
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