Transcriptional regulation of aldehyde dehydrogenase 1A1 gene by alternative spliced forms of nuclear factor Y in tumorigenic population of endometrial adenocarcinoma

• Main Authors: Mamat, Suhana, Ikeda, Jun-Ichiro, Tian, Tian, Wang, Yi, Luo, Wenjuan, Aozasa, Katsuyuki, Morii, Eiichi
• Format: Article
• Language: English
• Published: Sage Publications 2011
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/34093/1/1.pdf; http://irep.iium.edu.my/34093/; http://gan.sagepub.com/content/2/10/979.abstract
• Institution: Universiti Islam Antarabangsa Malaysia

High activity of aldehyde dehydrogenase (ALDH) is characteristic of normal and cancerous stem cells. Recently, high ALDH expression was shown to be associated with poor prognosis in uterine endometrial adenocarcinoma. The population with high ALDH activity (ALDH-hi) was more invasive, anti-apoptotic...