Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis

Osteoarthritis (OA) is the most common joint disorder characterised by bone remodelling and cartilage degradation and associated with chondrocyte apoptosis. These processes were investigated at 10, 16, 24, and 30 weeks in Dunkin Hartley (DH) and Bristol Strain 2 (BS2) guinea pigs that develop OA spo...

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Main Authors: Zamli, Zaitunnatakhin, Brown, Kate Robson, Tarlton, John F., Adams, Mike A., Torlot, Georgina E., Cartwright, Charlie, Cook, William A., Vassilevskaja, Kristiina, Sharif, Mohammed
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2014
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Online Access:http://irep.iium.edu.my/37057/1/Subchondral_Bone_Plate_Thickening_Precedes_Chondrocyte_Apoptosis_and_Cartilage_Degradation_in_Spontaneous_Animal_Models_of_Osteoarthritis.pdf
http://irep.iium.edu.my/37057/
http://dx.doi.org/10.1155/2014/606870
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Institution: Universiti Islam Antarabangsa Malaysia
Language: English
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spelling my.iium.irep.370572014-06-24T07:46:22Z http://irep.iium.edu.my/37057/ Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis Zamli, Zaitunnatakhin Brown, Kate Robson Tarlton, John F. Adams, Mike A. Torlot, Georgina E. Cartwright, Charlie Cook, William A. Vassilevskaja, Kristiina Sharif, Mohammed R Medicine (General) Osteoarthritis (OA) is the most common joint disorder characterised by bone remodelling and cartilage degradation and associated with chondrocyte apoptosis. These processes were investigated at 10, 16, 24, and 30 weeks in Dunkin Hartley (DH) and Bristol Strain 2 (BS2) guinea pigs that develop OA spontaneously. Both strains had a more pronounced chondrocyte apoptosis, cartilage degradation, and subchondral bone changes in the medial than the lateral side of the tibia, and between strains, the changes were always greater and faster in DH than BS2. In the medial side, a significant increase of chondrocyte apoptosis and cartilage degradation was observed in DH between 24 and 30 weeks of age preceded by a progressive thickening and stiffening of subchondral bone plate (Sbp). The Sbp thickness consistently increased over the 30-week study period but the bone mineral density (BMD) of the Sbp gradually decreased after 16 weeks. The absence of these changes in the medial side of BS2 may indicate that the Sbp of DH was undergoing remodelling. Chondrocyte apoptosis was largely confined to the deep zone of articular cartilage and correlated with thickness of the subchondral bone plate suggesting that cartilage degradation and chondrocyte apoptosis may be a consequence of continuous bone remodelling during the development of OA in these animal models of OA. Hindawi Publishing Corporation 2014 Article REM application/pdf en http://irep.iium.edu.my/37057/1/Subchondral_Bone_Plate_Thickening_Precedes_Chondrocyte_Apoptosis_and_Cartilage_Degradation_in_Spontaneous_Animal_Models_of_Osteoarthritis.pdf Zamli, Zaitunnatakhin and Brown, Kate Robson and Tarlton, John F. and Adams, Mike A. and Torlot, Georgina E. and Cartwright, Charlie and Cook, William A. and Vassilevskaja, Kristiina and Sharif, Mohammed (2014) Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis. BioMed Research International , 2014. pp. 1-10. ISSN 2314-6133 http://dx.doi.org/10.1155/2014/606870 doi:10.1155/2014/606870
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Zamli, Zaitunnatakhin
Brown, Kate Robson
Tarlton, John F.
Adams, Mike A.
Torlot, Georgina E.
Cartwright, Charlie
Cook, William A.
Vassilevskaja, Kristiina
Sharif, Mohammed
Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis
description Osteoarthritis (OA) is the most common joint disorder characterised by bone remodelling and cartilage degradation and associated with chondrocyte apoptosis. These processes were investigated at 10, 16, 24, and 30 weeks in Dunkin Hartley (DH) and Bristol Strain 2 (BS2) guinea pigs that develop OA spontaneously. Both strains had a more pronounced chondrocyte apoptosis, cartilage degradation, and subchondral bone changes in the medial than the lateral side of the tibia, and between strains, the changes were always greater and faster in DH than BS2. In the medial side, a significant increase of chondrocyte apoptosis and cartilage degradation was observed in DH between 24 and 30 weeks of age preceded by a progressive thickening and stiffening of subchondral bone plate (Sbp). The Sbp thickness consistently increased over the 30-week study period but the bone mineral density (BMD) of the Sbp gradually decreased after 16 weeks. The absence of these changes in the medial side of BS2 may indicate that the Sbp of DH was undergoing remodelling. Chondrocyte apoptosis was largely confined to the deep zone of articular cartilage and correlated with thickness of the subchondral bone plate suggesting that cartilage degradation and chondrocyte apoptosis may be a consequence of continuous bone remodelling during the development of OA in these animal models of OA.
format Article
author Zamli, Zaitunnatakhin
Brown, Kate Robson
Tarlton, John F.
Adams, Mike A.
Torlot, Georgina E.
Cartwright, Charlie
Cook, William A.
Vassilevskaja, Kristiina
Sharif, Mohammed
author_facet Zamli, Zaitunnatakhin
Brown, Kate Robson
Tarlton, John F.
Adams, Mike A.
Torlot, Georgina E.
Cartwright, Charlie
Cook, William A.
Vassilevskaja, Kristiina
Sharif, Mohammed
author_sort Zamli, Zaitunnatakhin
title Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis
title_short Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis
title_full Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis
title_fullStr Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis
title_full_unstemmed Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis
title_sort subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis
publisher Hindawi Publishing Corporation
publishDate 2014
url http://irep.iium.edu.my/37057/1/Subchondral_Bone_Plate_Thickening_Precedes_Chondrocyte_Apoptosis_and_Cartilage_Degradation_in_Spontaneous_Animal_Models_of_Osteoarthritis.pdf
http://irep.iium.edu.my/37057/
http://dx.doi.org/10.1155/2014/606870
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