Development of Halal modified release gliclazide 60 mg tablets by central composite design and production by direct compression

• Main Authors: Elsayed, Tarek Mohamed Ali, Mandal, Uttam Kumar, Kasmuri, Abdul Razak
• Format: Conference or Workshop Item
• Language: English
• Published: 2014
• Subjects: RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/38282/1/ICIP_2014.pdf; http://irep.iium.edu.my/38282/; http://www.iium.edu.my/icip2014/download/proceeding.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Background: Gliclazide is a second generation sulphonylurea drug used for the treatment of type 2 diabetes mellitus. Commercially available modified release (MR) gliclazide tablet is a once-daily formulation that employs a hydrophilic matrix of a hypromellose for drug release retardant activity. It...