Novel insight into the structural requirements of P70S6K inhibition using group-based quantitative structure activity relationship (GQSAR) (GQSAR)

• Main Authors: Abdullahi, Abubakar Danjuma, Mohammed Abdul Kader, Abdul Rahman, Abdul Samat, Nadia Hanis, Mohamed, Farahidah, Muhammad, Bala Yauri, Mohammed, Helaluddin Abul bashar, Aljarbou, Ahmed, Kasmuri, Abdul Razak
• Format: Article
• Language: English
• Published: Journal of Applied Pharmaceutical Science (http://www.japsonline.com) 2014
• Subjects: RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/41555/1/novel_insight_into_new_qsar_Japs.pdf; http://irep.iium.edu.my/41555/; http://www.japsonline.com
• Institution: Universiti Islam Antarabangsa Malaysia

Dysregulation of P70 ribosomal S6 kinase (P70S6K) has been observed in many cancers; therefore, the design of new molecules targeting p70S6K of paramount importance in cancer therapy. The current study employed a group-based quantitative structure-activity relationship (GQSAR) to develop global QS...