Articular cartilage restoration in load-bearing osteochondral defects by implantation of autologous chondrocyte-fibrin constructs: an experimental study in sheep

• Main Authors: Sha'ban, Munirah, Osman Cassim, Samsudin, Chen, Hui Cheng, S. H., Sharifah Salmah, Saim, Aminuddin, Idrus, Ruszymah
• Format: Article
• Language: English
• Published: The Journal of Bone and Joint Surgery 2007
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/41854/1/Munirah_et_al._2007.pdf; http://irep.iium.edu.my/41854/; http://www.jbjs.org.uk/
• Institution: Universiti Islam Antarabangsa Malaysia

Ovine articular chondrocytes were isolated from cartilage biopsy and culture expanded in vitro. Approximately 30 million cells per ml of cultured chondrocytes were incorporated with autologous plasma-derived fibrin to form a three-dimensional construct. Fullthickness punch hole defects were created...