Immunological Changes in Secondary Sjogran Syndrome (Comparative Study)

• Main Authors: Mustafa Al-Ahmad, Basma Ezzat, Mustafa, Nazih Shaban, Kashmola, Muhanad Ali Hamdon
• Format: Article
• Language: English; English
• Published: ELSEVIER 2015
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/42214/1/Immunological_Changes_in_Secondary_Sjogran_Syndrome.docx; http://irep.iium.edu.my/42214/5/Basma.pdf; http://irep.iium.edu.my/42214/
• Institution: Universiti Islam Antarabangsa Malaysia

Objective This study was designed to evaluate the immunological changes and its existence for early diagnosis and proper management of disease. Study Design 56 patients with RA accompanied by sSS where included in this study and compared to 60 RA patients without sSS.Schirmers test, blood tests and search for auto antibodies was done for all patients in both groups. Schirmers, blood tests and search for antinuclear antibody was done for all patients in both groups, with the measurement of salivary flow rate. Results Schirmers test was positive in all sSS and negative in all RA patients, whilst salivary flow rate was reduced in all sSS. Latex fixation test, ANA, Anti Ro and Anti La were reported significantly higher in sSS (p<0.01) Conclusions Secondary Sjogrens syndrome had a significantly positive rheumatoid factor, antinuclear antibody, anti Ro (SS-A) and anti La (SS-B) compared to rheumatoid patients without Sjogrens syndrome.