CD26: A prognostic marker of acute lymphoblastic leukemia in children in the post remission induction phase
Background: ALL is an irredeemable disease due to the resistance to treatment. There are several influences which are involved in such resistance to chemotherapy, including oxidative stress as a result of the generation of reactive oxygen species (ROS) and presence of hypodiploid cells. Cluster of...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Cancer Center, Korea.
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/44800/1/CD26_a_prognostic_markerfull.pdf http://irep.iium.edu.my/44800/ |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English |
| Summary: | Background: ALL is an irredeemable disease due to the resistance to treatment. There are several influences
which are involved in such resistance to chemotherapy, including oxidative stress as a result of the generation of
reactive oxygen species (ROS) and presence of hypodiploid cells. Cluster of differentiation 26 (CD26), also known
as dipeptidyl peptidase-4, is a 110 kDa, multifunctional, membrane-bound glycoprotein. Aim and objectives: The
aim of this study was to evaluate the clinical significance of serum CD26 in patients with acute lymphoblastic
leukaemia patients in the post remission induction phase, as well as the relationship between CD26 activity and
the oxidative stress status. Materials and Methods: CD26, total antioxidant status (TAS), total oxidant status
(TOS), and oxidative stress index (OSI), in addition to activity of related enzymes myeloperoxidase, glutathiones-
transferase and xanthine oxidase, were analysed in sixty children with acute lymphoblastic leukaemia in
the post remission induction phase. Results: The study showed significant elevation in CD26, TOS and OSI
levels in patients with acute lymphoblastic leukaemia in the post remission induction phase in comparison to
healthy control samples. In contrast, myeloperoxidase, glutathione-s-transferase and xanthine oxidase activities
were decreased significantly. A significant correlation between CD26 concentration and some oxidative stress
parameters was evident in ALL patients. Conclusions: Serum levels of CD26 appear to be useful as a new
biomarker of oxidative stress in children with acute lymphoblastic leukaemia in the post remission induction
phase, and levels of antioxidants must be regularly estimated during the treatment of children with ALL. |
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