Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis

• Main Authors: Pratama, Endrawan, Tian, Xiaohui, Lestari, Widya, Iseki, Sachiko, Arief Ichwan, Solachuddin Jauhari, Ikeda, Masa-Aki
• Format: Article
• Language: English
• Published: Elsevier 2015
• Subjects: RK Dentistry
• Online Access: http://irep.iium.edu.my/45991/1/Endrawan_BBRC_at_PUBMED.pdf; http://irep.iium.edu.my/45991/; http://www.sciencedirect.com/science/article/pii/S0006291X15308202
• Institution: Universiti Islam Antarabangsa Malaysia

ARID3A and ARID3B are transcriptional targets of p53. Recently, it has been reported that ARID3A plays a critical role in the transcriptional activation of pro-arrest p21 in response to DNA damage. However, the role of ARID3B in the p53 regulatory pathway remains poorly understood. Here we show th...