Methylation-specific PCR Revealed Aberrant Promoter Gene Methylation of p16, MGMT and SPOCK2 in Diffuse Large B-cell Lymphoma

• Main Authors: Mohd. Ridah, Lailatul Jalilah, Zainuddin, Norafiza, A. Talib, Norlelawati, Hussain, Faezahtul Arbaeyah
• Format: Conference or Workshop Item
• Language: English
• Published: 2015
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/54383/1/ICBHSR.pdf; http://irep.iium.edu.my/54383/
• Institution: Universiti Islam Antarabangsa Malaysia

DNA methylation silences the gene through addition of methyl group. p16, a tumor suppressor gene that inhibits cyclin-dependent kinase, inactivates the Rb protein and blocks G1 phase in a normal cell cycle. A DNA repair gene, MGMT removes alkyl adduct to a cysteine residue within the protein...