The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle

• Main Authors: Rostam, Muhamad Ashraf, Kamato, Danielle, Piva, Terence J., Zheng, Wenhua, Little, Peter J., Osman, Narin
• Format: Article
• Language: English; English; English
• Published: Elsevier Inc. 2016
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/54563/7/8.%20Rostam%20et%20al%202016.pdf; http://irep.iium.edu.my/54563/8/54563-The%20role%20of%20specific%20Smad%20linker%20region%20phosphorylation_SCOPUS.pdf; http://irep.iium.edu.my/54563/9/54563-The%20role%20of%20specific%20Smad%20linker%20region%20phosphorylation_WOS.pdf; http://irep.iium.edu.my/54563/; http://www.sciencedirect.com/science/article/pii/S0898656816300997
• Institution: Universiti Islam Antarabangsa Malaysia

Hyperelongation of glycosaminoglycan chains on proteoglycans facilitates increased lipoprotein binding in the blood vessel wall and the development of atherosclerosis. Increased mRNA expression of glycosaminoglycan chain synthesizing enzymes in vivo is associated with the development of atheroscle...