Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease

• Main Authors: Rostam, Muhamad Ashraf, Piva, Terence J., Rezaei, Hossein B., Kamato, Danielle, Little, Peter J., Zheng, Wenhua, Osman, Narin
• Format: Article
• Language: English; English
• Published: Wiley Online Library 2015
• Subjects: QP Physiology
• Online Access: http://irep.iium.edu.my/55276/1/3.%20Rostam-2015-Peptidyl-prolyl%20isomerases_%20Functi.pdf; http://irep.iium.edu.my/55276/7/55267-Peptidyl-prolyl%20isomerases_SCOPUS.pdf; http://irep.iium.edu.my/55276/; http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12335/full
• Institution: Universiti Islam Antarabangsa Malaysia

Peptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease. There are...