Methotrexate inhibits proliferation but not proteoglycan synthesis or glycosaminoglycan hyperelongation in human vascular smooth muscle cells

• Main Authors: Little, Peter J., Getachew, Robel, Kamato, Danielle, Rostam, Muhamad Ashraf, Cohen, Neale, Chan, Vincent, Osman, Narin
• Format: Article
• Language: English
• Published: OMICS International 2015
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/55384/1/9.%20Little%202015%20methotrexate-.pdf; http://irep.iium.edu.my/55384/; https://www.omicsonline.org/open-access/methotrexate-inhibits-proliferation-but-notproteoglycan-synthesis-or-glycosaminoglycan-hyperelongationin-human-vascular-smooth-muscle-cells-2161-1459-1000181.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Objectives: Atherosclerosis is a disease process involving the early deposition of lipids in the vessel wall trapped by modified proteoglycans and subsequently a chronic inflammatory process leading to the clinical events. MTX has been chosen to study the potential efficacy of an anti inflammatory...