Efficacy and safety of SPRINT and STAR protocol on Malaysian critically-ill patients

• Main Authors: Ahamad, Nurhamim, Abdul Razak, Normy Norfiza, Jamaludin, Ummu Kulthum, Suhaimi, Fatanah M., Pretty, Christopher G., Chase, Geoffrey, Md Ralib, Azrina, Mat Nor, Mohd Basri
• Format: Conference or Workshop Item
• Language: English; English; English
• Published: IEEE 2017
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/56098/7/56098%20Efficacy%20and%20safety%20of%20SPRINT%20and%20STAR%20protocol.pdf; http://irep.iium.edu.my/56098/8/56098%20Efficacy%20and%20safety%20of%20SPRINT%20and%20STAR%20SCOPUS.pdf; http://irep.iium.edu.my/56098/19/56098_Efficacy%20and%20safety%20of%20SPRINT%20and%20STAR_WOS.pdf; http://irep.iium.edu.my/56098/; http://ieeexplore.ieee.org/document/7843476/
• Institution: Universiti Islam Antarabangsa Malaysia

Abstract—Intensive care unit patients may have a better glycaemic management with the right control protocol. Results of virtual trial performance on Malaysian critically-ill patients adopting a model-derived and model-based control protocol known as SPRINT and STAR are presented in this paper. These ICU patients have been treated by intensive sliding-scale insulin infusion. The effectiveness and safety of glycaemic control are then analysed. Results showed that patient safety improved by 83% with SPRINT and STAR protocol as the number of hypoglycaemic patients significantly reduced (BG<2.2 mmol/L). Percentage of time within desired bands and median BG improves in both SPRINT and STAR. However the improvements are associated with higher number of BG measurements (workload).