In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.
The chemical composition of essential oils obtained from two parts of Piper magnibaccum C.DC. were analyzed by gas chromatography with a flame ionization detector (GC- FID) and gas chromatography- mass spectrometry (GC- MS). 25 components representing 93.5 % of the essential oil were characterized f...
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my.iium.irep.564572017-07-18T01:02:56Z http://irep.iium.edu.my/56457/ In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. Hashim, Nur Athirah Ahmad, Farediah Jani, Nor Akmalazura Darnis, Deny Susanti QD Chemistry The chemical composition of essential oils obtained from two parts of Piper magnibaccum C.DC. were analyzed by gas chromatography with a flame ionization detector (GC- FID) and gas chromatography- mass spectrometry (GC- MS). 25 components representing 93.5 % of the essential oil were characterized from the leaf of P. magnibaccum. The essential oil was dominated by germacrene D (40.8 %), β-caryophyllene (8.5 %) and α-cadinol (6.1 %). A total of 33 components, representing 87.6 % of the total oil were identified from the stem of P. magnibaccum. The major constituents were β-caryophyllene (19.7 %), germacrene D (10.7 %), and α- cadinol (8.2 %). The antioxidant potential of the leaf and stem essential oils of P. magnibaccum were determined on the basis of phenolic content and scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 20.5, 17.5 μg/mL) and 2,2’-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) (IC50 11.7, 12.9 μg/ mL) free radicals. Antityrosinase activity of the leaf and stem were also screened using mushroom tyrosinase assay (I %= 49.50±0.6, 57.01±0.8). The essential oil of P. magnibaccum leaf showed a moderate antibacterial activity with MIC value of 250 μg/mL against P. aeruginosa. None of the essential oils exhibited acute cytotoxicity against MCF-7 and A-549 cells proliferation. Taylor and Francis 2017 Article REM application/pdf en http://irep.iium.edu.my/56457/1/J.%20Essential%20oil%20Bearing%20Plants.pdf application/pdf en http://irep.iium.edu.my/56457/7/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/56457/8/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_WOS.pdf Hashim, Nur Athirah and Ahmad, Farediah and Jani, Nor Akmalazura and Darnis, Deny Susanti (2017) In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. Journal of Essential Oil Bearing Plants, 20 (1). pp. 223-232. ISSN 0972-060X http://www.tandfonline.com/doi/abs/10.1080/0972060X.2017.1282839 10.1080/0972060X.2017.1282839 |
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QD Chemistry Hashim, Nur Athirah Ahmad, Farediah Jani, Nor Akmalazura Darnis, Deny Susanti In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. |
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The chemical composition of essential oils obtained from two parts of Piper magnibaccum C.DC. were analyzed by gas chromatography with a flame ionization detector (GC- FID) and gas chromatography- mass spectrometry (GC- MS). 25 components representing 93.5 % of the essential oil were characterized from the leaf of P. magnibaccum. The essential oil was dominated by germacrene D (40.8 %), β-caryophyllene (8.5 %) and α-cadinol (6.1 %). A total of 33 components, representing 87.6 % of the total oil were identified from the stem of P. magnibaccum. The major constituents were β-caryophyllene (19.7 %), germacrene D (10.7 %), and α- cadinol (8.2 %). The antioxidant potential of the leaf and stem essential oils of P. magnibaccum were determined on the basis of phenolic content and scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 20.5, 17.5 μg/mL) and 2,2’-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) (IC50 11.7, 12.9 μg/ mL) free radicals. Antityrosinase activity of the leaf and stem were also screened using mushroom tyrosinase assay (I %= 49.50±0.6, 57.01±0.8). The essential oil of P. magnibaccum leaf showed a moderate antibacterial activity with MIC value of 250 μg/mL against P. aeruginosa. None of the essential oils exhibited acute cytotoxicity against MCF-7 and A-549 cells proliferation. |
format |
Article |
author |
Hashim, Nur Athirah Ahmad, Farediah Jani, Nor Akmalazura Darnis, Deny Susanti |
author_facet |
Hashim, Nur Athirah Ahmad, Farediah Jani, Nor Akmalazura Darnis, Deny Susanti |
author_sort |
Hashim, Nur Athirah |
title |
In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. |
title_short |
In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. |
title_full |
In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. |
title_fullStr |
In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. |
title_full_unstemmed |
In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. |
title_sort |
in vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum c. dc. |
publisher |
Taylor and Francis |
publishDate |
2017 |
url |
http://irep.iium.edu.my/56457/1/J.%20Essential%20oil%20Bearing%20Plants.pdf http://irep.iium.edu.my/56457/7/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_SCOPUS.pdf http://irep.iium.edu.my/56457/8/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_WOS.pdf http://irep.iium.edu.my/56457/ http://www.tandfonline.com/doi/abs/10.1080/0972060X.2017.1282839 |
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