In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.

The chemical composition of essential oils obtained from two parts of Piper magnibaccum C.DC. were analyzed by gas chromatography with a flame ionization detector (GC- FID) and gas chromatography- mass spectrometry (GC- MS). 25 components representing 93.5 % of the essential oil were characterized f...

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Main Authors: Hashim, Nur Athirah, Ahmad, Farediah, Jani, Nor Akmalazura, Darnis, Deny Susanti
Format: Article
Language:English
English
English
Published: Taylor and Francis 2017
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Online Access:http://irep.iium.edu.my/56457/1/J.%20Essential%20oil%20Bearing%20Plants.pdf
http://irep.iium.edu.my/56457/7/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_SCOPUS.pdf
http://irep.iium.edu.my/56457/8/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_WOS.pdf
http://irep.iium.edu.my/56457/
http://www.tandfonline.com/doi/abs/10.1080/0972060X.2017.1282839
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spelling my.iium.irep.564572017-07-18T01:02:56Z http://irep.iium.edu.my/56457/ In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. Hashim, Nur Athirah Ahmad, Farediah Jani, Nor Akmalazura Darnis, Deny Susanti QD Chemistry The chemical composition of essential oils obtained from two parts of Piper magnibaccum C.DC. were analyzed by gas chromatography with a flame ionization detector (GC- FID) and gas chromatography- mass spectrometry (GC- MS). 25 components representing 93.5 % of the essential oil were characterized from the leaf of P. magnibaccum. The essential oil was dominated by germacrene D (40.8 %), β-caryophyllene (8.5 %) and α-cadinol (6.1 %). A total of 33 components, representing 87.6 % of the total oil were identified from the stem of P. magnibaccum. The major constituents were β-caryophyllene (19.7 %), germacrene D (10.7 %), and α- cadinol (8.2 %). The antioxidant potential of the leaf and stem essential oils of P. magnibaccum were determined on the basis of phenolic content and scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 20.5, 17.5 μg/mL) and 2,2’-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) (IC50 11.7, 12.9 μg/ mL) free radicals. Antityrosinase activity of the leaf and stem were also screened using mushroom tyrosinase assay (I %= 49.50±0.6, 57.01±0.8). The essential oil of P. magnibaccum leaf showed a moderate antibacterial activity with MIC value of 250 μg/mL against P. aeruginosa. None of the essential oils exhibited acute cytotoxicity against MCF-7 and A-549 cells proliferation. Taylor and Francis 2017 Article REM application/pdf en http://irep.iium.edu.my/56457/1/J.%20Essential%20oil%20Bearing%20Plants.pdf application/pdf en http://irep.iium.edu.my/56457/7/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/56457/8/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_WOS.pdf Hashim, Nur Athirah and Ahmad, Farediah and Jani, Nor Akmalazura and Darnis, Deny Susanti (2017) In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. Journal of Essential Oil Bearing Plants, 20 (1). pp. 223-232. ISSN 0972-060X http://www.tandfonline.com/doi/abs/10.1080/0972060X.2017.1282839 10.1080/0972060X.2017.1282839
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic QD Chemistry
spellingShingle QD Chemistry
Hashim, Nur Athirah
Ahmad, Farediah
Jani, Nor Akmalazura
Darnis, Deny Susanti
In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.
description The chemical composition of essential oils obtained from two parts of Piper magnibaccum C.DC. were analyzed by gas chromatography with a flame ionization detector (GC- FID) and gas chromatography- mass spectrometry (GC- MS). 25 components representing 93.5 % of the essential oil were characterized from the leaf of P. magnibaccum. The essential oil was dominated by germacrene D (40.8 %), β-caryophyllene (8.5 %) and α-cadinol (6.1 %). A total of 33 components, representing 87.6 % of the total oil were identified from the stem of P. magnibaccum. The major constituents were β-caryophyllene (19.7 %), germacrene D (10.7 %), and α- cadinol (8.2 %). The antioxidant potential of the leaf and stem essential oils of P. magnibaccum were determined on the basis of phenolic content and scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 20.5, 17.5 μg/mL) and 2,2’-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) (IC50 11.7, 12.9 μg/ mL) free radicals. Antityrosinase activity of the leaf and stem were also screened using mushroom tyrosinase assay (I %= 49.50±0.6, 57.01±0.8). The essential oil of P. magnibaccum leaf showed a moderate antibacterial activity with MIC value of 250 μg/mL against P. aeruginosa. None of the essential oils exhibited acute cytotoxicity against MCF-7 and A-549 cells proliferation.
format Article
author Hashim, Nur Athirah
Ahmad, Farediah
Jani, Nor Akmalazura
Darnis, Deny Susanti
author_facet Hashim, Nur Athirah
Ahmad, Farediah
Jani, Nor Akmalazura
Darnis, Deny Susanti
author_sort Hashim, Nur Athirah
title In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.
title_short In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.
title_full In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.
title_fullStr In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.
title_full_unstemmed In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.
title_sort in vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum c. dc.
publisher Taylor and Francis
publishDate 2017
url http://irep.iium.edu.my/56457/1/J.%20Essential%20oil%20Bearing%20Plants.pdf
http://irep.iium.edu.my/56457/7/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_SCOPUS.pdf
http://irep.iium.edu.my/56457/8/56457-In%20vitro%20Antioxidant%2C%20Antityrosinase%2C%20Antibacterial_WOS.pdf
http://irep.iium.edu.my/56457/
http://www.tandfonline.com/doi/abs/10.1080/0972060X.2017.1282839
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