Synthesis and characterization of functionalized Se-MCM-41 a new drug carrier mesopore composite

• Main Authors: Rahman, Md. Mokhlesur, Md Aris, Mohd Aznan, Yusof, Alias Mohd, Ansaryr, H., Siddiqui, Mohammad Jamshed Ahmad, Yusan, S.
• Format: Article
• Language: English; English; English
• Published: Oriental Scientific Publishing Company 2017
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/56753/7/56753_Synthesis%20and%20characterization%20of%20functionalized%20Se-MCM-41_Scopus.pdf; http://irep.iium.edu.my/56753/13/56753_Synthesis%20and%20characterization%20of%20functionalized.pdf; http://irep.iium.edu.my/56753/14/56753_Synthesis%20and%20characterization%20of%20functionalized_WOS.pdf; http://irep.iium.edu.my/56753/; http://www.orientjchem.org/vol33no2/synthesis-and-characterization-of-functionalized-se-mcm-41-a-new-drug-carrier-mesopore-composite/
• Institution: Universiti Islam Antarabangsa Malaysia

Various nanocomposite materials play a number of important roles in modern science and technology including pharmaceutical science. Among these materials, mesoporous materials cover a large number of applications in drug delivery system. The quantitative incorporation and high dispersion of selenium nanoparticles into MCM-41 have been made possible by the coordination between Se(IV) ion and aminopropyltriethoxysilane (APTES)-anchored MCM-41. The samples were characterized by X-ray powder diffraction, Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM), nitrogen adsorption–desorption via multi-point Brunauer, Emmett and Teller (BET) analysis, Raman spectroscopy and UV-Vis diffusion reflection spectroscopy (UV-vis/DRS). The increase in cell parameter and the decrease in surface area observed by N2 adsorption-desorption technique were taken as evidence of selenium introduction inside the MCM-41 framework. The behaviour of drug release in these nanocomposites is probably due to hydrogen bonding interactions between drug and the hydroxyl group on the composite framework.