Expression of collagenases matrix metalloproteinases and YB-1 oncogenic factor in malignant melanoma cancer cells and its regulation by stromal fibroblasts

• Main Authors: Ibrahim, Wisam Nabeel, Abdul Wahab, Ridhwan, Abdull Rasad, Mohammad Syaiful Bahari
• Format: Article
• Language: English; English
• Published: Asian Network of Scienctific Information 2017
• Subjects: RB Pathology; RL Dermatology
• Online Access: http://irep.iium.edu.my/57172/2/17-25_3.pdf; http://irep.iium.edu.my/57172/8/Expression%20of%20collagenases%20matrix%20metalloproteinases%20and%20YB-1%20oncogenic%20factor%20in%20malignant%20melanoma%20cancer%20cells%20and%20its%20regulation%20by%20stromal%20fibroblasts.pdf; http://irep.iium.edu.my/57172/; http://scialert.net/qredirect.php?doi=ijcr.2017.17.25&linkid=pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Background and Objective: Fibroblast stromal cells actively participates in tumor invasion by secreting matrix metalloproteinases (MMPs) within the tumor microenvironment. Expression of these enzymes is primarily regulated at a transcriptional level via interaction with transcription factors. Amon...