In vivo study of the pharmacokinetic effect of amlodipine and gliclazide

• Main Authors: Helal Uddin, A.B.M., Alaama, Mohammed, Awang, Mohamed, Abbas, Syed Atif
• Format: Conference or Workshop Item
• Language: English
• Published: Centre of Lipids Engineering and Applied Research (CLEAR), Universiti Teknologi Malaysia (UTM) 2017
• Subjects: QD Chemistry; RS Pharmacy and materia medica; RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/60342/1/ICOST%202017.pdf; http://irep.iium.edu.my/60342/; https://clear.utm.my/icost2017/
• Institution: Universiti Islam Antarabangsa Malaysia

It was found that there is kind of pharmacodynamic interaction between calcium channels blockers and sulfonylurea. The addition of amlodipine (AMLO) to gliclazide (GLZ) course caused significant decrease in glucose lowering effect of GLZ. The mechanism of AMLO-GLZ interaction is not well understood....