LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis

• Main Authors: Mohamed Sideek, Mohamed Arshad, Menz, Clementine, Parsi, Mahroo K., Gibson, Mark A.
• Format: Article
• Language: English
• Published: Elsevier B.V 2013
• Subjects: RB Pathology
• Online Access: http://irep.iium.edu.my/62192/1/LTBP-2%20Elastin%20paper%20-%20Matrix%20Biology.pdf; http://irep.iium.edu.my/62192/; https://ac.els-cdn.com/S0945053X13001364/1-s2.0-S0945053X13001364-main.pdf?_tid=spdf-2c68457b-e3ef-4363-91c6-5f682de6219e&acdnat=1519534042_5e02880ee8831bfb58b39415e61ab31b
• Institution: Universiti Islam Antarabangsa Malaysia

Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) is a protein of ill-defined function associated with elastic fibers during elastinogenesis. Although LTBP-2 binds fibrillin-1, fibulin-5, and heparin/heparan sulfate, molecules critical for normal elastic fiber assembly, it does not...