LTBP-2 has a single high-affinity binding site for FGF-2 and blocks FGF-2-induced cell proliferation.

• Main Authors: Menz, Clementine, K. Parsi, Mahroo, R. J. Adams, Julian, Mohamed Sideek, Mohamed Arshad, Kopecki, Zlatko, J. Cowin, Allison, Gibson, Mark A.
• Format: Article
• Language: English; English
• Published: Public Library of Science 2015
• Subjects: RB Pathology
• Online Access: http://irep.iium.edu.my/62193/1/LTBP-2%20FGF-2%20paper%20-%20PLOS%20One.pdf; http://irep.iium.edu.my/62193/7/62193_LTBP-2%20has%20a%20single%20high-affinity%20binding_scopus.pdf; http://irep.iium.edu.my/62193/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532469/pdf/pone.0135577.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) belongs to the fibrillin-LTBP superfamily of extracellular matrix proteins. LTBPs and fibrillins are involved in the sequestration and storage of latent growth factors, particularly transforming growth factor β (TGF-β), in tissues....