Screening of fatty acid compound of S. polycystum for anti-cariogenic potential
Introduction: Dental caries is the most common yet preventable disease. Study found that seaweed exhibits anti-cariogenic properties. However, little attention have been given to the study on anticariogenic properties of seaweed and the bioactive compound that responsible for the anticariogenic act...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Medical Journal Malaysia
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62599/1/62599_Screening%20Of%20Fatty%20Acid%20Compound.pdf http://irep.iium.edu.my/62599/ http://iiumedic.net/imjm/v1/volume-16-supplementary-issue-no-2/ |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English |
| Summary: | Introduction: Dental caries is the most common yet preventable disease. Study found that seaweed
exhibits anti-cariogenic properties. However, little attention have been given to the study on anticariogenic properties of seaweed and the bioactive compound that responsible for the anticariogenic activities have not adequately investigated. This study was conducted to evaluate the
best extraction methods for S. polycystum and to determine the fatty acid compounds of S.
polycystum that have anti-cariogenic potential against oral cariogenic bacteria. Materials and
Methods: Dried seaweeds were extracted by soxhlet using three different solvents (methanol,
dichloromethane and hexane). The crude extracts were kept in a close container at -20 degree
Celsius. The bioactive compound of the crude extract of seaweeds was analyzed using Gas
Chromatography Mass Spectrometer (GCMS). Results: Highest extraction yield in S. polycystum was
produced by methanol extraction followed by hexane and dichloromethane. GCMS analysis revealed
that the presence of palmitic acid (18.02%) as major compound, followed by oleic acid (8.44%),
lauric acid (5.23%), myristic acid (3.60%), heptadecanoic acid (2.23%), 9-hexadenoic acid (1.82%)
and the lowest is 2-methylhexadecan-1-ol (1.75%). Conclusion(s): Methanol extraction is the most
efficient solvent as it produced the highest extraction yield in S. polycystum.Lauric acid, palmitic
acid, myristic acid and oleic acid detected in S. polycystum have been reported to exhibit
antimicrobial activities thus proved the potentiality of S. polycystum as anti-cariogenic agent. |
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