Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity

• Main Authors: Awaad, Amani Shafeek, Alafeefy, Ahmed Mahmoud, Alasmary, Fatmah A.S., El-Meligy, Reham M., Zain, Mohamed E., Alqasoumi, Saleh Ibrahim
• Format: Article
• Language: English; English
• Published: King Saud University 2017
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://irep.iium.edu.my/62988/1/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_article.pdf; http://irep.iium.edu.my/62988/2/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_scopus.pdf; http://irep.iium.edu.my/62988/; https://ac.els-cdn.com/S1319016417300336/1-s2.0-S1319016417300336-main.pdf?_tid=65296070-a4b4-4070-87ff-74fafe7351e2&acdnat=1521772234_e894eeedbc735db615b2bce506872115
• Institution: Universiti Islam Antarabangsa Malaysia

A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging.