QSAR modeling for anti-human African trypanosomiasis activity of substituted 2-phenylimidazopyridines

• Main Authors: Masand, Vijay Hariram, El-Sayed, Nahed Nasser Eid, Mahajan, Devidas T., Mercader, Andrew G., Alafeefy, Ahmed Mahmoud, Shibi, Indira G.
• 格式: Article
• 語言: English; English; English
• 出版: Elsevier 2017
• 主題: Q Science (General); QD Chemistry
• 在線閱讀: http://irep.iium.edu.my/63003/1/63003_QSAR%20modeling%20for%20anti-human%20African.pdf; http://irep.iium.edu.my/63003/2/63003_QSAR%20modeling%20for%20anti-human%20African_SCOPUS.pdf; http://irep.iium.edu.my/63003/3/63003_QSAR%20modeling%20for%20anti-human%20African_WOS.pdf; http://irep.iium.edu.my/63003/; https://www.sciencedirect.com/science/article/abs/pii/S0022286016311681
• 機構: Universiti Islam Antarabangsa Malaysia

In the present work, sixty substituted 2-Phenylimidazopyridines previously reported with potent anti-human African trypanosomiasis (HAT) activity were selected to build genetic algorithm (GA) based QSAR models to determine the structural features that have significant correlation with the activity....