Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis

• Main Authors: Ashour, Abdelkader Elbadawy Abbas, Abd-Allah, Adel R. A., Korashy, Hesham M., Attia, Sabry M., Alzahrani, Abderlrahman Z., Saquib, Quaiser, Bakheet, Saleh A., Abdel-Hamied, Hala E.
• Format: Article
• Language: English; English
• Published: Springer US 2014
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/63263/1/8129_Thymoquinone%20suppression%20of%20the%20human.pdf; http://irep.iium.edu.my/63263/2/8129_Thymoquinone%20suppression%20of%20the%20human_SCOPUS.pdf; http://irep.iium.edu.my/63263/; https://link.springer.com/article/10.1007%2Fs11010-013-1930-1
• Institution: Universiti Islam Antarabangsa Malaysia

Hepatocellular carcinoma (HCC) is the fourth most common solid tumor worldwide. The chemokine interleukin-8 (IL-8) is overexpressed in HCC and is a potential target for therapy. Although the transcription factor NF-κB regulates IL-8 expression, and while thymoquinone (TQ; the most bioactive constitu...