Synthesis, characterization and preliminary study on acetylpyrazine N(4)butylthiosemicarbazone as a potential CDK2 inhibitor combined with DFT calculations

• Main Authors: Abdullah, Erna Normaya, Ahmad, Mohammad Norazmi, Abdul Aziz, Yang Farina, Ku Bulat, Ku Halim
• Format: Article
• Language: English; English
• Published: JBCS Editorial and Publishing Office 2018
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/63804/13/63804_Synthesis%2C%20characterization%20and%20preliminary%20study%20on%20acetylpyrazine_article.pdf; http://irep.iium.edu.my/63804/7/63804%20Synthesis%2C%20Characterization%20and%20Preliminary%20Study%20WOS.pdf; http://irep.iium.edu.my/63804/; http://jbcs.sbq.org.br/imagebank/pdf/2018-0024AR.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

In this study, a new thiosemicarbazone ligand, namely acetylpyrazine N(4)butylthiosemicarbazone (APBT), was synthesized and characterized using 1H and 13C nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) spectroscopies. Quantum chemical calculations were performed using density...