Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

• Main Authors: Mahamad Maifiah, Mohd Hafidz, Cheah, Soon-Ee, Johnson, Matthew D., Han, Mei-Ling, Boyce, John D., Thamlikitkul, Visanu, Forrest, Alan, Kaye, Keith S., Hertzog, Paul, Purcell, Anthony W., Song, Jiangning, Velkov, Tony, Creek, Darren J., Li, Jian
• Format: Article
• Language: English
• Published: Springer Nature 2016
• Subjects: QR Microbiology; RM Therapeutics. Pharmacology; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/65378/1/2016_SciRep.pdf; http://irep.iium.edu.my/65378/; https://www.nature.com/articles/srep22287.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Multidrug-resistant Acinetobacter baumannii presents a global medical crisis and polymyxins are used as the last-line therapy. This study aimed to identify metabolic differences between polymyxinsusceptible and polymyxin-resistant A. baumannii using untargeted metabolomics. The metabolome of each...