Novel docetaxel chitosan-coated PLGA/PCL nanoparticles with magnified cytotoxicity and bioavailability

• Main Authors: Badran, Mohamed M., Alomrani, Abdullah Hasan, Harisa, Gamaleldin I., Ashour, Abdelkader Elbadawy Abbas, Kumar, Ashok, Yassin, Alaa Eldeen Bakry
• Format: Article
• Language: English; English; English
• Published: Elsevier Masson 2018
• Subjects: RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/65898/1/65898_Novel%20docetaxel%20chitosan-coated.pdf; http://irep.iium.edu.my/65898/2/65898_Novel%20docetaxel%20chitosan-coated_SCOPUS.pdf; http://irep.iium.edu.my/65898/3/65898_Novel%20docetaxel%20chitosan-coated_WOS.pdf; http://irep.iium.edu.my/65898/; https://www.sciencedirect.com/science/article/abs/pii/S0753332218328063
• Institution: Universiti Islam Antarabangsa Malaysia

In the present study, docetaxel (DTX)-loaded poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) nanoparticles were successfully prepared and coated with chitosan (CS). The prepared nanoparticles (NPs) were evaluated for their particle size, zeta potential, particle morphology, drug entr...