Synthesis, characterization and cytotoxic activity of S-benzyldithiocarbazate Schiff bases derived from 5-fluoroisatin, 5-chloroisatin, 5-bromoisatin and their crystal structures

• Main Authors: Abdul Manan, Mohd Abdul Fatah, Crouse, Karen Anne, Mohamed Tahir, Mohamed Ibrahim, Rosli, Rozita, How, Fiona Ni Foong, Watkins, David J., Slawin, Alexandra Martha Zoya
• Format: Article
• Language: English
• Published: Springer New York LLC 2011
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/7866/1/JOCC_41_1630-1641.pdf; http://irep.iium.edu.my/7866/; http://www.springerlink.com/content/8x5872603784m7p7/
• Institution: Universiti Islam Antarabangsa Malaysia

Schiff bases were prepared from S-benzyldithiocarbazate with 5-fluro-, 5-chloro- and 5-bromoisatin. All are potential tridentate nitrogen, oxygen, sulfur donors. They were found to be selectively active against MCF-7 cell line (Human non-metastatic mammary gland adenocarcinoma cell line). The bro...