Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis
Cell imprint lithography (CIL) or cell replication plays a vital role in fields like biomimetic smart culture substrates, bone tissue engineering, cell guiding, cell adhesion, tissue engineering, cell microenvironments, tissue microenvironments, cell research, drug delivery, diagnostics, therapeut...
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my.iium.irep.798242020-06-25T06:02:43Z http://irep.iium.edu.my/79824/ Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis Narayanamurthy, Vigneswaran Samsuri, Fahmi Firus Khan, Al'aina Yuhainis Hamzah, Hairul Aini Baharom, Madia Baizura Kumary, Thrikkovil Variathu Anil Kumar, Pallickaveedu Rajanasari Raj, Deepa K. NE2250 Lithography QC Physics RE Ophthalmology Cell imprint lithography (CIL) or cell replication plays a vital role in fields like biomimetic smart culture substrates, bone tissue engineering, cell guiding, cell adhesion, tissue engineering, cell microenvironments, tissue microenvironments, cell research, drug delivery, diagnostics, therapeutics and many other applications. Herein we report a new formulation of superconductive carbon black photopolymer composite and its characterization towards a CIL process technique. In this article, we demonstrated an approach of using a carbon nanoparticle-polymer composite (CPC) for patterning cells. It is observed that a 0.3 wt % load of carbon nanoparticles (CNPs) in a carbon polymer mixture (CPM) was optimal for cell-imprint replica fabrication. The electrical resistance of the 3-CPC (0.3 wt %) was reduced by 68% when compared to N-CPC (0 wt %). This method successfully replicated the single cell with sub-organelle scale. The shape of microvesicles, grooves, pores, blebs or microvilli on the cellular surface was patterned clearly. This technique delivers a free-standing cell feature substrate. In vitro evaluation of the polymer demonstrated it as an ideal candidate for biomimetic biomaterial applications. This approach also finds its application in study based on morphology, especially for drug delivery applications and for investigations based on molecular pathways. Institute of Physics Publishing 2020 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/79824/1/79824_Direct%20cell%20imprint%20lithography%20in%20superconductive_article.pdf application/pdf ar http://irep.iium.edu.my/79824/2/79824_Direct%20cell%20imprint%20lithography%20in%20superconductive_scopus.pdf Narayanamurthy, Vigneswaran and Samsuri, Fahmi and Firus Khan, Al'aina Yuhainis and Hamzah, Hairul Aini and Baharom, Madia Baizura and Kumary, Thrikkovil Variathu and Anil Kumar, Pallickaveedu Rajanasari and Raj, Deepa K. (2020) Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis. Bioinspiration and Biomimetics, 15 (1). pp. 1-15. ISSN 1748-3182 E-ISSN 1748-3190 https://iopscience.iop.org/article/10.1088/1748-3190/ab1243 10.1088/1748-3190/ab1243 |
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NE2250 Lithography QC Physics RE Ophthalmology Narayanamurthy, Vigneswaran Samsuri, Fahmi Firus Khan, Al'aina Yuhainis Hamzah, Hairul Aini Baharom, Madia Baizura Kumary, Thrikkovil Variathu Anil Kumar, Pallickaveedu Rajanasari Raj, Deepa K. Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis |
description |
Cell imprint lithography (CIL) or cell replication plays a vital role in fields like biomimetic smart
culture substrates, bone tissue engineering, cell guiding, cell adhesion, tissue engineering, cell
microenvironments, tissue microenvironments, cell research, drug delivery, diagnostics, therapeutics
and many other applications. Herein we report a new formulation of superconductive carbon black
photopolymer composite and its characterization towards a CIL process technique. In this article, we
demonstrated an approach of using a carbon nanoparticle-polymer composite (CPC) for patterning
cells. It is observed that a 0.3 wt % load of carbon nanoparticles (CNPs) in a carbon polymer mixture
(CPM) was optimal for cell-imprint replica fabrication. The electrical resistance of the 3-CPC (0.3 wt %)
was reduced by 68% when compared to N-CPC (0 wt %). This method successfully replicated the
single cell with sub-organelle scale. The shape of microvesicles, grooves, pores, blebs or microvilli
on the cellular surface was patterned clearly. This technique delivers a free-standing cell feature
substrate. In vitro evaluation of the polymer demonstrated it as an ideal candidate for biomimetic
biomaterial applications. This approach also finds its application in study based on morphology,
especially for drug delivery applications and for investigations based on molecular pathways. |
format |
Article |
author |
Narayanamurthy, Vigneswaran Samsuri, Fahmi Firus Khan, Al'aina Yuhainis Hamzah, Hairul Aini Baharom, Madia Baizura Kumary, Thrikkovil Variathu Anil Kumar, Pallickaveedu Rajanasari Raj, Deepa K. |
author_facet |
Narayanamurthy, Vigneswaran Samsuri, Fahmi Firus Khan, Al'aina Yuhainis Hamzah, Hairul Aini Baharom, Madia Baizura Kumary, Thrikkovil Variathu Anil Kumar, Pallickaveedu Rajanasari Raj, Deepa K. |
author_sort |
Narayanamurthy, Vigneswaran |
title |
Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis |
title_short |
Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis |
title_full |
Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis |
title_fullStr |
Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis |
title_full_unstemmed |
Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis |
title_sort |
direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis |
publisher |
Institute of Physics Publishing |
publishDate |
2020 |
url |
http://irep.iium.edu.my/79824/1/79824_Direct%20cell%20imprint%20lithography%20in%20superconductive_article.pdf http://irep.iium.edu.my/79824/2/79824_Direct%20cell%20imprint%20lithography%20in%20superconductive_scopus.pdf http://irep.iium.edu.my/79824/ https://iopscience.iop.org/article/10.1088/1748-3190/ab1243 |
_version_ |
1672610180728094720 |