Synthesis and characterization of orotic acid loaded chitosan inclusion complex
The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/ CS was carried out using fourier transform infrared spectro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
International Journal of Drug Delivery Technology
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/82571/7/82571_Synthesis%20and%20characterization%20of%20orotic%20acid%20loaded%20chitosan%20inclusion%20complex.pdf http://irep.iium.edu.my/82571/13/82571_Synthesis%20and%20characterization.pdf http://irep.iium.edu.my/82571/ https://ijddt.com/volume10issue1/ |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English English |
| Summary: | The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS).
The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/
CS was carried out using fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), differential scanning
calorimetry (DSC), zeta sizer, and transmission electron microscopy (TEM). Furthermore, the size of OA/CS ranged between
58 nm and 200 nm, and the zeta potential was 30 mV. Thus, this study indicates that OA/CS has a promising future to develop
a carrier for drug delivery systems further.
Keywords: Chitosan, Drug delivery, Inclusion complex, Orotic acid, Synthesis.
International Journal of Drug Delivery Technology (2020); DOI: 10.25258/ijddt.10.1.1
How to cite this article: Hassani A, Azad AK, Enezei HH, Hussain SA, Helal Uddin ABM. Synthesis and Characterization
of Orotic Acid Loaded Chitosan Inclusion Complex. International Journal of Drug Delivery Technology. 2020; 10(1): 1-4. |
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