Role of O6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O6-alkylating agents

• Main Authors: Thompson, M. J., Abdul Rahman, Suzanah, Baker, T. G., Rafferty, J. A, Margison, G. P., Bibby, M. C
• Format: Article
• Language: English
• Published: Society for Reproduction and Fertility 2000
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/8407/1/J._Reprod_fertility.pdf; http://irep.iium.edu.my/8407/
• Institution: Universiti Islam Antarabangsa Malaysia

The O6-alkylguanine-DNA alkyltransferase inactivator O6-benzylguanine was administered to BALB/c mice either alone or before exposure to 1,3-bis(2-chloroethyl)- 1-nitrosourea to study the role of the DNA repair protein O6-alkylguanine-DNA alkyltransferase in the protection of the testis against a...