Mode of action of 5-acetyl-4-methylthiazole derivatives as antimicrobial agents

• Main Authors: Abdullah Ripain, Iswatun Hasanah, Ngah, Nurziana, Darnis, Deny Susanti
• Format: Article
• Language: English; English
• Published: Faculty of Science and Technology, Universiti Kebangsaan Malaysia 2021
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/90572/7/90572_Mode%20of%20action%20of%205-acetyl-4-methylthiazole%20derivatives%20as%20antimicrobial%20agents.pdf; http://irep.iium.edu.my/90572/8/90572_Mode%20of%20action%20of%205-acetyl-4-methylthiazole%20derivatives_Scopus.pdf; http://irep.iium.edu.my/90572/; https://mjas.analis.com.my/mjas/v25_n2/pdf/Iswatun_25_2_14.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Thiazole derivatives have been widely known to possess antimicrobial behaviour. The purpose of this study is to investigate the mode of antimicrobial actions of synthesised thiazole compounds on Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Salmonella typhimurium), and fungus (Candida albicans). Three synthesised thiazole compounds namely 5-acetyl-4-methyl-2-(3,4-dichloroaniline)-1,3-thiazole (T1), 5-acetyl-4-methyl-2-(4-aminophenol)-1,3-thiazole (T2), and 5-acetyl-4-methyl-2-(methyl-4-aminobenzoate)-1,3-thiazole (T3) were evaluated in the mode of action assays such as salt tolerance, time-killing, crystal violet and leakage 260/280 nm absorbing materials. The result showed that the T3 compound exhibited the best performance for all tested assays at a concentration equal to 4 × MIC compared to T1 and T2.