The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)
Background: International guidelines recommend the use of indirect calorimetry (IC) to measure energy requirements in critically ill patients. This study aimed to assess the effects of IC-guided nutrition vs standard-nutrition care on clinical outcomes in critically ill patients. Methods: Sixty m...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
IIUM Press
2021
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/91493/1/91493_The%20Impact%20Of%20Indirect%20Calorimetry%20Guided%20Feeding%20Protocol.pdf http://irep.iium.edu.my/91493/ https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/583 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English |
| Summary: | Background: International guidelines recommend the use of indirect calorimetry (IC) to measure energy requirements in critically ill patients.
This study aimed to assess the effects of IC-guided nutrition vs standard-nutrition care on clinical outcomes in critically ill patients.
Methods: Sixty mechanically ventilated patients expected to stay in intensive care unit (ICU) more than 3 days were randomized into a group in which energy needs were determined by IC (IC-group) and a group prescribed with 25kcal/kg/day reflecting standard care (SC-group). The primary outcome was the ICU length of stay(LOS). Secondary outcomes included change in quadriceps muscle layer thickness (QMLT, ultrasound) during the first 10 days of ICU admission, hospital-LOS, duration of mechanical ventilation, ICU mortality and 28-day-in hospital mortality.
Results: Mean energy requirement was similar in both groups. The IC group received 85.63%, whereas the SC group received 76.83% of their energy goals (P=0.002). The protein intake was higher in the IC group (89.58% vs 77.66%, p=0.007). Both groups had a median of 8.0 days ICU-LOS (p=0.424). QMLT was decreased in both groups by 21.9% vs. 25.3% at day10 (p < 0.001), respectively. However, there were no significant differences observed in muscle mass changes and other secondary clinical outcomes between the groups.
Conclusion: IC-guided nutrition did not appear to affect significantly any clinical outcomes compared to the SC group due to the limitation in Sample size.
Clinicaltrials.gov identifier no. NCT04479254 |
|---|