PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity

• Main Authors: Poli, Alessandro, Abdul-Hamid, Shidqiyyah, Zaurito, Antonio Enrico, Campagnoli, Francesca, Bevilacqua, Valeria, Sheth, Bhavwanti, Fiume, Roberta, Pagani, Massimiliano, Abrignani, Sergio, Divecha, Nullin
• Format: Article
• Language: English; English
• Published: National Academy of Sciences 2021
• Subjects: Q Science (General); QP Physiology
• Online Access: http://irep.iium.edu.my/92431/1/92431_PIP4Ks%20impact%20on%20PI3K%2C%20FOXP3%2C%20and%20UHRF1%20signaling.pdf; http://irep.iium.edu.my/92431/2/92431_PIP4Ks%20impact%20on%20PI3K%2C%20FOXP3%2C%20and%20UHRF1%20signaling_SCOPUS.pdf; http://irep.iium.edu.my/92431/; https://www.pnas.org/content/118/31/e2010053118.short; https://doi.org/10.1073/pnas.2010053118
• Institution: Universiti Islam Antarabangsa Malaysia

Regulatory T cells (Tregs) play fundamental roles in maintaining peripheral tolerance to prevent autoimmunity and limit legitimate immune responses, a feature hijacked in tumor microenvironments in which the recruitment of Tregs often extinguishes immune surveillance through suppression of T-effecto...