Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review

Scaffolds support and promote the formation of new functional tissues through cellular interactions with living cells. Various types of scaffolds have found their way into biomedical science, particularly in tissue engineering. Scaffolds with a superior tissue regenerative capacity must be biocompat...

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Main Authors: Ahmad Ruzaidi, Dania Adila, Mahat, Mohd Muzamir, Shafiee, Saiful 'Arifin, Mohamed Sofian, Zarif, Mohmad Sabere, Awis Sukarni, Ramli, Rosmamuhamadani, Osman, Hazwanee, Hamzah, Hairul Hisham, Zainal Ariffin, Zaidah, Sadasivuni, Kishor Kumar
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Language:English
English
English
Published: Multidisciplinary Digital Publishing Institute (MDPI) 2021
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Online Access:http://irep.iium.edu.my/93166/7/93166_Advocating%20electrically%20conductive%20scaffolds.pdf
http://irep.iium.edu.my/93166/18/93166_Advocating%20electrically%20conductive%20scaffolds.pdf
http://irep.iium.edu.my/93166/19/93166_Advocating%20electrically%20conductive%20scaffolds_WoS.pdf
http://irep.iium.edu.my/93166/
https://www.mdpi.com/2073-4360/13/19/3395/pdf
https://doi.org/10.3390/polym13193395
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spelling my.iium.irep.931662021-10-27T07:43:08Z http://irep.iium.edu.my/93166/ Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review Ahmad Ruzaidi, Dania Adila Mahat, Mohd Muzamir Shafiee, Saiful 'Arifin Mohamed Sofian, Zarif Mohmad Sabere, Awis Sukarni Ramli, Rosmamuhamadani Osman, Hazwanee Hamzah, Hairul Hisham Zainal Ariffin, Zaidah Sadasivuni, Kishor Kumar Q Science (General) Scaffolds support and promote the formation of new functional tissues through cellular interactions with living cells. Various types of scaffolds have found their way into biomedical science, particularly in tissue engineering. Scaffolds with a superior tissue regenerative capacity must be biocompatible and biodegradable, and must possess excellent functionality and bioactivity. The different polymers that are used in fabricating scaffolds can influence these parameters. Polysaccharide-based polymers, such as collagen and chitosan, exhibit exceptional biocompatibility and biodegradability, while the degradability of synthetic polymers can be improved using chemical modifications. However, these modifications require multiple steps of chemical reactions to be carried out, which could potentially compromise the end product’s biosafety. At present, conducting polymers, such as poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate) (PEDOT: PSS), polyaniline, and polypyrrole, are often incorporated into matrix scaffolds to produce electrically conductive scaffold composites. However, this will reduce the biodegradability rate of scaffolds and, therefore, agitate their biocompatibility. This article discusses the current trends in fabricating electrically conductive scaffolds, and provides some insight regarding how their immunogenicity performance can be interlinked with their physical and biodegradability properties. Multidisciplinary Digital Publishing Institute (MDPI) 2021-10-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/93166/7/93166_Advocating%20electrically%20conductive%20scaffolds.pdf application/pdf en http://irep.iium.edu.my/93166/18/93166_Advocating%20electrically%20conductive%20scaffolds.pdf application/pdf en http://irep.iium.edu.my/93166/19/93166_Advocating%20electrically%20conductive%20scaffolds_WoS.pdf Ahmad Ruzaidi, Dania Adila and Mahat, Mohd Muzamir and Shafiee, Saiful 'Arifin and Mohamed Sofian, Zarif and Mohmad Sabere, Awis Sukarni and Ramli, Rosmamuhamadani and Osman, Hazwanee and Hamzah, Hairul Hisham and Zainal Ariffin, Zaidah and Sadasivuni, Kishor Kumar (2021) Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review. Polymers, 13 (19). pp. 1-27. ISSN 2073-4360 https://www.mdpi.com/2073-4360/13/19/3395/pdf https://doi.org/10.3390/polym13193395
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic Q Science (General)
spellingShingle Q Science (General)
Ahmad Ruzaidi, Dania Adila
Mahat, Mohd Muzamir
Shafiee, Saiful 'Arifin
Mohamed Sofian, Zarif
Mohmad Sabere, Awis Sukarni
Ramli, Rosmamuhamadani
Osman, Hazwanee
Hamzah, Hairul Hisham
Zainal Ariffin, Zaidah
Sadasivuni, Kishor Kumar
Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review
description Scaffolds support and promote the formation of new functional tissues through cellular interactions with living cells. Various types of scaffolds have found their way into biomedical science, particularly in tissue engineering. Scaffolds with a superior tissue regenerative capacity must be biocompatible and biodegradable, and must possess excellent functionality and bioactivity. The different polymers that are used in fabricating scaffolds can influence these parameters. Polysaccharide-based polymers, such as collagen and chitosan, exhibit exceptional biocompatibility and biodegradability, while the degradability of synthetic polymers can be improved using chemical modifications. However, these modifications require multiple steps of chemical reactions to be carried out, which could potentially compromise the end product’s biosafety. At present, conducting polymers, such as poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate) (PEDOT: PSS), polyaniline, and polypyrrole, are often incorporated into matrix scaffolds to produce electrically conductive scaffold composites. However, this will reduce the biodegradability rate of scaffolds and, therefore, agitate their biocompatibility. This article discusses the current trends in fabricating electrically conductive scaffolds, and provides some insight regarding how their immunogenicity performance can be interlinked with their physical and biodegradability properties.
format Article
author Ahmad Ruzaidi, Dania Adila
Mahat, Mohd Muzamir
Shafiee, Saiful 'Arifin
Mohamed Sofian, Zarif
Mohmad Sabere, Awis Sukarni
Ramli, Rosmamuhamadani
Osman, Hazwanee
Hamzah, Hairul Hisham
Zainal Ariffin, Zaidah
Sadasivuni, Kishor Kumar
author_facet Ahmad Ruzaidi, Dania Adila
Mahat, Mohd Muzamir
Shafiee, Saiful 'Arifin
Mohamed Sofian, Zarif
Mohmad Sabere, Awis Sukarni
Ramli, Rosmamuhamadani
Osman, Hazwanee
Hamzah, Hairul Hisham
Zainal Ariffin, Zaidah
Sadasivuni, Kishor Kumar
author_sort Ahmad Ruzaidi, Dania Adila
title Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review
title_short Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review
title_full Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review
title_fullStr Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review
title_full_unstemmed Advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review
title_sort advocating electrically conductive scaffolds with low immunogenicity for biomedical applications: a review
publisher Multidisciplinary Digital Publishing Institute (MDPI)
publishDate 2021
url http://irep.iium.edu.my/93166/7/93166_Advocating%20electrically%20conductive%20scaffolds.pdf
http://irep.iium.edu.my/93166/18/93166_Advocating%20electrically%20conductive%20scaffolds.pdf
http://irep.iium.edu.my/93166/19/93166_Advocating%20electrically%20conductive%20scaffolds_WoS.pdf
http://irep.iium.edu.my/93166/
https://www.mdpi.com/2073-4360/13/19/3395/pdf
https://doi.org/10.3390/polym13193395
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