Relationship of selective complement markers with schizophrenia

Immune system dysregulation may be involved in schizophrenia, but biomarker studies have thus far reported inconsistent findings. The relationship of plasma levels of complement markers C3 and C4, with schizophrenia, sociodemographic and clinico-psychological factors were here studied in 183 patient...

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Main Authors: Abdull Jalil, Mohd Asyraf, Abd Rahim, Nour El Huda, Mohd Noor, Hanisah, Ku Zaifah, Norsidah, A.Talib, Norlelawati
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語言:English
English
出版: 2021
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在線閱讀:http://irep.iium.edu.my/95714/1/Accepted%20manuscript%20-%20complement%20markers%20in%20schizophrenia.pdf
http://irep.iium.edu.my/95714/7/95714_Relationship%20of%20selective%20complement%20markers%20with%20schizophrenia_SCOPUS.pdf
http://irep.iium.edu.my/95714/
https://www.sciencedirect.com/journal/journal-of-neuroimmunology
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spelling my.iium.irep.957142022-01-12T02:58:08Z http://irep.iium.edu.my/95714/ Relationship of selective complement markers with schizophrenia Abdull Jalil, Mohd Asyraf Abd Rahim, Nour El Huda Mohd Noor, Hanisah Ku Zaifah, Norsidah A.Talib, Norlelawati QR180 Immunology RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Immune system dysregulation may be involved in schizophrenia, but biomarker studies have thus far reported inconsistent findings. The relationship of plasma levels of complement markers C3 and C4, with schizophrenia, sociodemographic and clinico-psychological factors were here studied in 183 patients and 212 controls. C3 and C4 levels were significantly higher in the patients and in subjects with elevated C-reactive protein (CRP), and positively correlated with body mass index (BMI) (p <0.05). Schizophrenia, BMI, and CRP were significant predictors for C3 and C4 levels in multivariate analyses (p <0.001). In conclusion, complements C3 and C4 are potential peripheral biomarkers in schizophrenia. 2021-02-15 Article PeerReviewed application/pdf en cc_by_nc_nd http://irep.iium.edu.my/95714/1/Accepted%20manuscript%20-%20complement%20markers%20in%20schizophrenia.pdf application/pdf en http://irep.iium.edu.my/95714/7/95714_Relationship%20of%20selective%20complement%20markers%20with%20schizophrenia_SCOPUS.pdf Abdull Jalil, Mohd Asyraf and Abd Rahim, Nour El Huda and Mohd Noor, Hanisah and Ku Zaifah, Norsidah and A.Talib, Norlelawati (2021) Relationship of selective complement markers with schizophrenia. Journal of Neuroimmunology, 363. ISSN 0165-5728 (In Press) https://www.sciencedirect.com/journal/journal-of-neuroimmunology 10.1016/j.jneuroim.2021.577793
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QR180 Immunology
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle QR180 Immunology
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Abdull Jalil, Mohd Asyraf
Abd Rahim, Nour El Huda
Mohd Noor, Hanisah
Ku Zaifah, Norsidah
A.Talib, Norlelawati
Relationship of selective complement markers with schizophrenia
description Immune system dysregulation may be involved in schizophrenia, but biomarker studies have thus far reported inconsistent findings. The relationship of plasma levels of complement markers C3 and C4, with schizophrenia, sociodemographic and clinico-psychological factors were here studied in 183 patients and 212 controls. C3 and C4 levels were significantly higher in the patients and in subjects with elevated C-reactive protein (CRP), and positively correlated with body mass index (BMI) (p <0.05). Schizophrenia, BMI, and CRP were significant predictors for C3 and C4 levels in multivariate analyses (p <0.001). In conclusion, complements C3 and C4 are potential peripheral biomarkers in schizophrenia.
format Article
author Abdull Jalil, Mohd Asyraf
Abd Rahim, Nour El Huda
Mohd Noor, Hanisah
Ku Zaifah, Norsidah
A.Talib, Norlelawati
author_facet Abdull Jalil, Mohd Asyraf
Abd Rahim, Nour El Huda
Mohd Noor, Hanisah
Ku Zaifah, Norsidah
A.Talib, Norlelawati
author_sort Abdull Jalil, Mohd Asyraf
title Relationship of selective complement markers with schizophrenia
title_short Relationship of selective complement markers with schizophrenia
title_full Relationship of selective complement markers with schizophrenia
title_fullStr Relationship of selective complement markers with schizophrenia
title_full_unstemmed Relationship of selective complement markers with schizophrenia
title_sort relationship of selective complement markers with schizophrenia
publishDate 2021
url http://irep.iium.edu.my/95714/1/Accepted%20manuscript%20-%20complement%20markers%20in%20schizophrenia.pdf
http://irep.iium.edu.my/95714/7/95714_Relationship%20of%20selective%20complement%20markers%20with%20schizophrenia_SCOPUS.pdf
http://irep.iium.edu.my/95714/
https://www.sciencedirect.com/journal/journal-of-neuroimmunology
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