Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition
P2X4 is a ligand-gated cation channel activated by extracellular ATP involved in neuropathic pain, inflammation and arterial tone. Natural products were screened against human or mouse P2X4 activity using fura-2 loaded 1321N1 cells for measurement of intracellular Ca2+ responses. Whole-cell currents...
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Main Authors: | , , , , , , |
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Format: | Article |
Language: | English English |
Published: |
John Wiley and Sons Inc
2021
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Subjects: | |
Online Access: | http://irep.iium.edu.my/98808/7/98808_Taspine%20is%20a%20natural%20product.pdf http://irep.iium.edu.my/98808/8/98808_Taspine%20is%20a%20natural%20product_Scopus.pdf http://irep.iium.edu.my/98808/ https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15663 |
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Institution: | Universiti Islam Antarabangsa Malaysia |
Language: | English English |