Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition

Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition

P2X4 is a ligand-gated cation channel activated by extracellular ATP involved in neuropathic pain, inflammation and arterial tone. Natural products were screened against human or mouse P2X4 activity using fura-2 loaded 1321N1 cells for measurement of intracellular Ca2+ responses. Whole-cell currents...

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Bibliographic Details
Main Authors: Ahmad Nadzirin, Izzuddin, Fortuny-Gomez, Anna, Ngum, Neville, Richards, David, Ali, Seema, Searcey, Mark, J. Fountain, Samuel
Format: Article
Language:English
English
Published: John Wiley and Sons Inc 2021
Subjects:
QP Physiology
Online Access:http://irep.iium.edu.my/98808/7/98808_Taspine%20is%20a%20natural%20product.pdf
http://irep.iium.edu.my/98808/8/98808_Taspine%20is%20a%20natural%20product_Scopus.pdf
http://irep.iium.edu.my/98808/
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15663
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Institution: Universiti Islam Antarabangsa Malaysia
Language: English
English

Internet

http://irep.iium.edu.my/98808/7/98808_Taspine%20is%20a%20natural%20product.pdf
http://irep.iium.edu.my/98808/8/98808_Taspine%20is%20a%20natural%20product_Scopus.pdf
http://irep.iium.edu.my/98808/
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15663

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