Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect

Core-shell Fe3O4/Au nanostructures were constructed using an advanced method of two-step synthesis from Juglans regia (walnut) green husk extract. Several complementary methods were applied to investigate structural and magnetic properties of the samples. X-ray diffraction (XRD), high-resolution tra...

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Main Authors: Izadiyan, Zara, Shameli, Kamyar, Miyake, Mikio, Teow, Sin Yeang *, Peh, Suat Cheng *, Shaza Eva M, Siti Husnaa, M T
Format: Article
Language:English
Published: Elsevier 2019
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Online Access:http://eprints.sunway.edu.my/1147/1/Teow%20Sin%20Yeang%20Green%20fabrication%20of-1.pdf
http://eprints.sunway.edu.my/1147/
http://doi.org/10.1016/j.msec.2018.11.008
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spelling my.sunway.eprints.11472019-11-27T08:29:57Z http://eprints.sunway.edu.my/1147/ Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect Izadiyan, Zara Shameli, Kamyar Miyake, Mikio Teow, Sin Yeang * Peh, Suat Cheng * Shaza Eva M, Siti Husnaa, M T RC0254 Neoplasms. Tumors. Oncology (including Cancer) Core-shell Fe3O4/Au nanostructures were constructed using an advanced method of two-step synthesis from Juglans regia (walnut) green husk extract. Several complementary methods were applied to investigate structural and magnetic properties of the samples. X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), electron diffraction, optical, thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM) were used for nanoparticle characterizations. As shown by HR-TEM, the mean diameter of core-shell Fe3O4/Au nanoparticles synthesized using co-precipitation method was 6.08 ± 1.06 nm. This study shows that the physical and structural properties of core-shell Fe3O4/Au nanoparticles possess intrinsic properties of gold and magnetite. VSM revealed that the core-shell Fe3O4/Au have high saturation magnetization and low coercivity due to the magnetic properties. The core-shell nanoparticles show the inhibitory concentration (IC)50 of 235 μg/ml against a colorectal cancer cell line, HT-29. When tested against non-cancer cells, IC50 was not achieved even up to 500 μg/ml. This study highlights the magnetic properties and anticancer action of core-shell Fe3O4/Au nanoparticles. This compound can be ideal candidate for cancer treatment and other biomedical applications. Elsevier 2019-11-06 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/1147/1/Teow%20Sin%20Yeang%20Green%20fabrication%20of-1.pdf Izadiyan, Zara and Shameli, Kamyar and Miyake, Mikio and Teow, Sin Yeang * and Peh, Suat Cheng * and Shaza Eva M, and Siti Husnaa, M T (2019) Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect. Materials Science and Engineering: C, 96. pp. 51-57. ISSN 09284931 http://doi.org/10.1016/j.msec.2018.11.008 doi:10.1016/j.msec.2018.11.008
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
language English
topic RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Izadiyan, Zara
Shameli, Kamyar
Miyake, Mikio
Teow, Sin Yeang *
Peh, Suat Cheng *
Shaza Eva M,
Siti Husnaa, M T
Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect
description Core-shell Fe3O4/Au nanostructures were constructed using an advanced method of two-step synthesis from Juglans regia (walnut) green husk extract. Several complementary methods were applied to investigate structural and magnetic properties of the samples. X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), electron diffraction, optical, thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM) were used for nanoparticle characterizations. As shown by HR-TEM, the mean diameter of core-shell Fe3O4/Au nanoparticles synthesized using co-precipitation method was 6.08 ± 1.06 nm. This study shows that the physical and structural properties of core-shell Fe3O4/Au nanoparticles possess intrinsic properties of gold and magnetite. VSM revealed that the core-shell Fe3O4/Au have high saturation magnetization and low coercivity due to the magnetic properties. The core-shell nanoparticles show the inhibitory concentration (IC)50 of 235 μg/ml against a colorectal cancer cell line, HT-29. When tested against non-cancer cells, IC50 was not achieved even up to 500 μg/ml. This study highlights the magnetic properties and anticancer action of core-shell Fe3O4/Au nanoparticles. This compound can be ideal candidate for cancer treatment and other biomedical applications.
format Article
author Izadiyan, Zara
Shameli, Kamyar
Miyake, Mikio
Teow, Sin Yeang *
Peh, Suat Cheng *
Shaza Eva M,
Siti Husnaa, M T
author_facet Izadiyan, Zara
Shameli, Kamyar
Miyake, Mikio
Teow, Sin Yeang *
Peh, Suat Cheng *
Shaza Eva M,
Siti Husnaa, M T
author_sort Izadiyan, Zara
title Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect
title_short Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect
title_full Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect
title_fullStr Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect
title_full_unstemmed Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect
title_sort green fabrication of biologically active magnetic core-shell fe3o4/au nanoparticles and their potential anticancer effect
publisher Elsevier
publishDate 2019
url http://eprints.sunway.edu.my/1147/1/Teow%20Sin%20Yeang%20Green%20fabrication%20of-1.pdf
http://eprints.sunway.edu.my/1147/
http://doi.org/10.1016/j.msec.2018.11.008
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