Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography

Highly crystalline titanium dioxide nanoparticles (TiO2 -NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2 -NPs are tested for improvement in two modes of kilovoltage radiation therapy and singlephoton emission...

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Main Authors: Khalid, A., Ahmad, P., Alharthi, A. I., Muhammad, S., Khandaker, Mayeen Uddin *, Faruque, M. R. I., Din, I. U., Alotaibi, M. A.
Format: Article
Language:English
Published: MDPI 2021
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Online Access:http://eprints.sunway.edu.my/1668/1/Mayeen%20Unmodified%20Titanium.pdf
http://eprints.sunway.edu.my/1668/
http://doi.org/10.3390/cryst11020171
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spelling my.sunway.eprints.16682021-04-19T03:59:38Z http://eprints.sunway.edu.my/1668/ Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography Khalid, A. Ahmad, P. Alharthi, A. I. Muhammad, S. Khandaker, Mayeen Uddin * Faruque, M. R. I. Din, I. U. Alotaibi, M. A. R895-920 Medical Physics/Medical Radiology Highly crystalline titanium dioxide nanoparticles (TiO2 -NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2 -NPs are tested for improvement in two modes of kilovoltage radiation therapy and singlephoton emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2 -NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2 -NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2 -NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer. MDPI 2021 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1668/1/Mayeen%20Unmodified%20Titanium.pdf Khalid, A. and Ahmad, P. and Alharthi, A. I. and Muhammad, S. and Khandaker, Mayeen Uddin * and Faruque, M. R. I. and Din, I. U. and Alotaibi, M. A. (2021) Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography. Crystals, 11 (2). p. 171. ISSN 2073-4352 http://doi.org/10.3390/cryst11020171 doi:10.3390/cryst11020171
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
language English
topic R895-920 Medical Physics/Medical Radiology
spellingShingle R895-920 Medical Physics/Medical Radiology
Khalid, A.
Ahmad, P.
Alharthi, A. I.
Muhammad, S.
Khandaker, Mayeen Uddin *
Faruque, M. R. I.
Din, I. U.
Alotaibi, M. A.
Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography
description Highly crystalline titanium dioxide nanoparticles (TiO2 -NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2 -NPs are tested for improvement in two modes of kilovoltage radiation therapy and singlephoton emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2 -NPs provide an observable enhancement in CT scan image contrast ranging from 0 ± 3 HU (without NPs) to 283.7 ± 3 HU (0.23 g/mL). TiO2 -NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2 -NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.
format Article
author Khalid, A.
Ahmad, P.
Alharthi, A. I.
Muhammad, S.
Khandaker, Mayeen Uddin *
Faruque, M. R. I.
Din, I. U.
Alotaibi, M. A.
author_facet Khalid, A.
Ahmad, P.
Alharthi, A. I.
Muhammad, S.
Khandaker, Mayeen Uddin *
Faruque, M. R. I.
Din, I. U.
Alotaibi, M. A.
author_sort Khalid, A.
title Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography
title_short Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography
title_full Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography
title_fullStr Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography
title_full_unstemmed Unmodified Titanium Dioxide Nanoparticles as a potential contrast agent in photon emission computed tomography
title_sort unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography
publisher MDPI
publishDate 2021
url http://eprints.sunway.edu.my/1668/1/Mayeen%20Unmodified%20Titanium.pdf
http://eprints.sunway.edu.my/1668/
http://doi.org/10.3390/cryst11020171
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