5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment

• Main Authors: Yusefi, Mostafa, Soon, M. L. K., Shameli, Kamyar, Teow, Sin Yeang *, Ali, Roshafima Rasit, Siew, K. K., Chan, H. Y., Wong, Magdelyn Mei Theing *, Lim, Wei Ling *, Kuča, K.
• Format: Article
• Language: English
• Published: Elsevier 2021
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.sunway.edu.my/1829/1/Ronald%20Teow%205%20Fluorouacil%20carbohydrate%20polymer.pdf; http://eprints.sunway.edu.my/1829/; http://doi.org/10.1016/j.carbpol.2021.118523
• Institution: Sunway University

Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-Fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments.