QSAR modelling to predict structural features of certain sulfonamide as Urokinase-type Plasminogen Activator inhibitors

• Main Authors: Jawarkar, Rahul D, Zaki, Magdi E A, Al-Hussain, Sami, Alzahrani, Abdullah Yahya Abdullah, Long, Chiau Ming *, Samad, Abdul, Ingle, Rahul G., Mali, Suraj N.
• Format: Article
• Published: Elsevier 2024
• Subjects: QP Physiology; RM Therapeutics. Pharmacology
• Online Access: http://eprints.sunway.edu.my/2611/; https://doi.org/10.1016/j.chphi.2024.100544
• Institution: Sunway University

The serine hydrolase family includes serine proteases. It is essential for hydrolyzing protein peptide bonds and breaking them. The urokinase-type plasminogen activator (uPA) selectively binds to the uPAR on numerous cell types, including cancer cells. Pericellular proteolysis of cell-bound proteins...