The ERBB2 Exonic Variant Pro1170Ala Modulates Mitogen-Activated Protein Kinase Signaling Cascades and Associates with Allergic Asthma

• Main Authors: Sio, Yang Yie, Gan, Wei Liang, Ng, Wing Shan, Matta, Sri Anusha, Say, Yee How*, Teh, Keng Foo *, Wong, Yi Ru *, Smyrna Moti, Rawanan Shah *, Kavita, Reginald *, Chew, Fook Tim
• Format: Article
• Published: Karger Publishers 2023
• Subjects: QP Physiology; QR Microbiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2669/; https://doi.org/10.1159/000530960
• Institution: Sunway University

Introduction: Previous studies have indicated the ERBB2 genetic variants in the 17q12 locus might be associated with asthma; however, the functional effects of these variants on asthma risk remain inconclusive. This study aimed to characterize the functional roles of asthma-associated ERBB2 single n...