Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington’s disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms

• Main Authors: Lum, Pei Teng, Mahendran, Sekar, Seow, Lay Jing, Shaikh, Mohd Farooq, Alina, Arulsamy, Thaarvena, Retinasamy, Gan, Siew Hua, Gnanaraj, Charles, Norhaizan, Mohd Esa, Gobinath, Ramachawolran, Vetriselvan, Subramaniyan, Chinni, Suresh V, Wu, Yuan Seng *
• Format: Article
• Published: Frontiers Media 2023
• Subjects: QD Chemistry; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2767/; https://doi.org/10.3389/fphar.2023.1189957
• Institution: Sunway University

Huntington’s disease (HD), a neurodegenerative disease, normally starts in the prime of adult life, followed by a gradual occurrence of psychiatric disturbances, cognitive and motor dysfunction. The daily performances and life quality of HD patients have been severely interfered by these clinical si...