Stylopine: A potential natural metabolite to activate vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy

• Main Authors: Velayutham, Naveen Kumar, Thamaraikani, Tamilanban, Wahab, Shadma, Khalid, Mohammad, Gobinath, Ramachawolran, Abullais, Shahabe Saquib, Wong, Ling Shing, Mahendran, Sekar, Gan, Siew Hua, Ebenezer, Angel Jemima, Ravikumar, Mrinalini, Subramaniyan, Vetriselvan, Nur Najihah, Izzati Mat Rani, Wu, Yuan Seng *, Jeyabalan, Srikanth
• Format: Article
• Published: Frontiers Media 2023
• Subjects: QL Zoology; QP Physiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2777/; https://doi.org/10.3389/fphar.2023.1150270
• Institution: Sunway University

Vascular endothelial growth factor (VEGF) signals cell survival, cell migration, osteogenesis, cell proliferation, angiogenesis, and vascular permeability by binding to VEGF receptor 2 (VEGFR-2). Osteosarcoma is the most common primary bone cancer, majorly affects young adults. Activation of VEGFR-2...