Nano-mediated strategy for targeting and treatment of non-small cell lung cancer (NSCLC)

• Main Authors: Ashique, Sumel, Garg, Ashish, Mishra, Neeraj, Raina, Neha, Long, Chiau Ming *, Tulli, Hardeep Singh, Behl, Tapan, Rani, Radha, Gupta, Madhu
• Format: Article
• Published: Springer 2023
• Subjects: RC Internal medicine; RS Pharmacy and materia medica
• Online Access: http://eprints.sunway.edu.my/2820/; https://link.springer.com/article/10.1007/s00210-023-02522-5
• Institution: Sunway University

Lung cancer is the most common type of cancer, with over 2.1 million cases diagnosed annually worldwide. It has a high incidence and mortality rate, leading to extensive research into various treatment options, including the use of nanomaterial-based carriers for drug delivery. With regard to cancer treatment, the distinct biological and physico-chemical features of nano-structures have acquired considerable impetus as drug delivery system (DDS) for delivering medication combinations or combining diagnostics and targeted therapy. This review focuses on the use of nanomedicine-based drug delivery systems in the treatment of lung cancer, including the use of lipid, polymer, and carbon-based nanomaterials for traditional therapies such as chemotherapy, radiotherapy, and phototherapy. The review also discusses the potential of stimuli-responsive nanomaterials for drug delivery in lung cancer, and the limitations and opportunities for improving the design of nano-based materials for the treatment of non-small cell lung cancer (NSCLC).